I think that there are a few genres/genre variants which these past years died a very sorry death and now are so fraught and loaded with stereotypes and "have it seen already" that it's useless to write them during the next decade or so. Vampires and werewolves definitely belong there in my opinion. Also most "urban fantasy," by now I yawn when such stuff is on on TV and I have ceased to be even mildly interested in stories or books. SciFi also has suffered, as have medieval fantasy, pirates and Roman gladiator stiories. What has ceased working for you?