This topic seems to be done to death. And usually I'm on the side of "cliches are good if you do them right". But I wonder if the answer could change based on the specific character and the genre we're talking about. I like writing mystery stories, and one of the biggest cliches in that genre is the male protagonist that is really good at what he does, but he's also very cynical and in some cases something happened to him to make him cynical (suffering a loss of some kind). For example, Jane from The Mentalist or Dr. House from House MD. I had an idea for a story, and the whole point of the story isn't the character that's suffered a loss or anything like that... but the story doesn't really work too well without that type of character in it.