The narrator slammed the door behind him and ran over to the pages, setting about adding as many adjectives that would make the door more resistant as possible. Sturdy. Tough. Impervious. Reinforced. Afterwards he looked at the protagonist's axe, and started adding descriptions there as well, seeking to change its properties to something that would keep him safe. Comical. Rusty. Ineffective. The thuds stopped. Silence. "Please." Came a voice from behind it, one filled with frustration and desperation. "I need you to stop. The constant character growth, the love triangles, the endless array of sequels. Please, I just, I need to be left alone, to live my life. The narrator sighed, taking the pages in hand and walking over to the door. "I, I can't. I'm trapped the same as you are." "But you're the one creating all this." She murmured, as the door was unlocked, the narrator gesturing her to come inside. She took a few tentative steps inwards, before the narrator gestured to the pages. She didn't look at them, instead turning to face him. "This is all I am to you, isn't it, words on paper. Having my entire life steered, having my family and friends suffer. Why, what could possibly justify all of this. The narrator took a deep breath, and pointed upwards. Her head tilted back and she saw it, and then felt it. They'd always been there, always looking down on her. Every single poignant memory now held the sound of breathing overhead. Every dangerous moment with the creatures anticipation and eagerness. "I, I'm entertainment." The narrator nodded. "After all I've been put though, this is all that it's been for. All the misery and suffering and confusion." Another nod. "There has to be a way to stop it. There has to be. It can't go on like this, I can't go on like this." The narrator pointed at the pages once again. "Two words, that's all you need to write to finish this. To stop this whole saga." The Protagonist picked up the small, black pen, examining it for a moment. She could do wonders with this. She could fix all the ills of the world. Ensure no one ever went hungry. Bring back all her friends and loved ones, who'd she'd grown so deeply attached to. She felt the beast smile. No, that was what it wanted. What did their deaths mean if they just came back to entertain it. She looked up at the sky for one last time, meeting the beast's eyes for a moment, before setting the pen to the page, and writing two words. The End.
I think the idea of antagonizing the reader directly could actually work. It could be direct, just a pummeling of the reader's sensibilities, morals, and psyche, appealing to the masochists in the world. Or it could be indirect, subtly challenging and annoying the reader. I think the latter could actually be an excellent form of oratory.
Oh, that reminds me, The Stanly Parable is a great example of this. I suggest watching a lets play on youtube without commentary.
You really have to play it for the full affect though. A similar game with a meta element is Spec Ops: The Line, where I'd argue that the player is the direct antagonist Spoiler: Spoiler where the player's control of the character forces him to do horrifying stuff.
This would be best done in a choose your own adventure book. Except instead of the reader being the protag each option presented to the reader is a way to thwart the protag instead.
Also Protagonist is just the main character not hero/villain so making the protag a villain and the antag a hero is possible
This is pretty old as far as flash games go, but its a fun reader 'antag' game. http://mostfungames.com/do-not-press-the-red-button.htm
This is what I was going to suggest. I have the entire Lone Wolf series of books and had them since I was a kid. I have a few Steve Jackson ones and I thought they were great. In these series the reader is the protagonist so it would be interesting to see one where the reader is the antagonist. Actually this brings up a rather philosophical question - can you really be the antagonist in your own story? I know that people can be "evil" but the antagonist isn't always a "baddie" he is simply the rival to the hero in any given story. If you are the antagonist who is the protagonist?