There is nothing new under the sun, and that's okay. The only thing that will be truly unique about what you write is you--your perspective, your voice, your style. Execute the most mundane, cliche'd plot really, really well, and you'll have one hell of a story.
I don't think there is something original that happened in this world. It is difficult to get the sympathy of readers if they can't relate in the event in your story or if they have a hard time imagining it in case of a fantasy story. I suggest you to be creative in the way you present your story even though the setting and plot is quite used by other novels. You can use the same plot and setting as long as the conversation and the flow of the story is uniquely presented. Just take ''The Notebook'' of Nicholas Spark for example. The plot of the story is widely use and very common, with the boy and girl within a different level of financial status and a typical conflict where the parents of the girl do not approve of the guy to be their daughter's partner. This is a very common story but what made the notebook unique is the memorable conversation and other unique events that surrounded the plot.
Original plot ideas and the like still exist; they're just harder to find in well-mined territory. Don't let the lack of a truly fresh, unique plot twist or other element keep you from writing. Originality is also (though never solely) in the choices you make in combining all the different parts of a compelling story.