My hero is onboard a transcontinental bus in Kansas. He has just discovered that he is being framed for a murder which occurred in Texas (the origin point for the bus). The guy who framed him is also on the bus and is headed for New York to set off a bomb. What does the hero do? If he stays on the bus, the cops will eventually catch up to him. If he gets off the bus, then he's stuck in the middle of nowhere Kansas and won't be able to stop the bomb from going off. Suggestions, please
If the police knew he was on the bus, they would stop the bus before it arrived. Even if it slipped through their immediate jurisdiction, they'd know the bus's route and get the state authorities to stop the bus and arrest the guy. It would be really, really unlikely they'd just shrug and say, "Oh, well. We'll get him on the other side of the country." So, assuming they don't know he's on the bus, there's no reason for him not to go to New York.
My assumption is that they don't know he's on the bus until after the corpse is found and video tapes are reviewed. By the time they know he's on the bus, the bus is in Kansas on a long stretch of road in the middle of wheat fields.
To me it's a bit illogical for the antagonist to frame a guy who's on the same bus as him. Seems like it would impede him more than anything. If I were this character, I would want the person I'm framing to be somewhere else, preferably far away while I commit a crime.