Just curious about the opinion on this out there. Why I ask is that we all like to read about what we know. And given that most people (including writers and critics) live in big cities, particularly those on the coast, will a writer have an instant bias toward acceptance and greater sales if he/she uses one of the big three or four as the setting for her novel? (NY, LA, SanFran, etc.) This is assuming that all other considerations, such as quality, are set aside. I am working on a murder/mystery set in a small town in Wisconsin: the setting is ideal for the plot but I'm somewhat concerned as the setting is so obscure.